China's first coronavirus hospital OPENS today

China‘s first dedicated coronavirus hospital has opened in a city near Wuhan after workers and volunteers spent just two days converting an empty building to a 1,000-bed emergency facility.

The first batch of coronavirus patients were transferred to the Dabie Mountain Regional Medical Centre in Huanggang at around 10:30pm local time on Tuesday.     

The extra capacity will be crucial for overwhelmed medical staff in Hubei, the locked-down province at the centre of the crisis.

Another hospital is being purpose-built from scratch in Wuhan 47 miles (75km) away and is expected to be completed later this week after just a week of construction. 

More than 6,000 people around the world are now confirmed to have been infected with the Wuhan coronavirus and 132 have died in China.

The United Arab Emirates (UAE) has become the latest country to declare cases – an unknown number among a family travelling from China – and Germany has now diagnosed four people with the infection.

Germany also yesterday revealed it had hosted the first human-to-human transmission in Europe, 웹소설 추천 between a German man and a woman travelling from China. 

The latest developments in the Wuhan coronavirus crisis include: 

The Dabie Mountain Regional Medical Centre is the first dedicated coronavirus hospital to have opened in China. Workers and volunteers spent two days revamping an empty building

The Dabie Mountain Regional Medical Centre is the first dedicated coronavirus hospital to have opened in China.

Workers and 웹소설 추천 volunteers spent two days revamping an empty building

By Monday, all of the beds had been set up by volunteers, and water, electricity and internet had also been connected, according to the government of Huanggang

By Monday, all of the beds had been set up by volunteers, and water, electricity and internet had also been connected, according to the government of Huanggang

A handout image from the Huanggang government shows workers from the city's electricity company working to connect the building to the grid so it can treat coronavirus patients

A handout image from the Huanggang government shows workers from the city’s electricity company working to connect the building to the grid so it can treat coronavirus patients

A picture released by the Huanggang government shows construction workers installing necessary facilities on the site of Dabie Mountain Regional Medical Centre on January 25

A picture released by the Huanggang government shows construction workers installing necessary facilities on the site of Dabie Mountain Regional Medical Centre on January 25

The infection has spread to at least 18 countries or territories outside of China, including the US, Canada, France and Germany

The infection has spread to at least 18 countries or territories outside of China, including the US, Canada, 웹소설 추천 France and Germany

A pilot wearing a protective suit parks a cargo plane at Wuhan's Tianhe International Airport on Tuesday

A pilot wearing a protective suit parks a cargo plane at Wuhan’s Tianhe International Airport on Tuesday

Medical workers are pictured treating a severely-ill coronavirus patient with pneumonia in Zhongnan Hospital in Wuhan, the city at the centre of the outbreak

Medical workers are pictured treating a severely-ill coronavirus patient with pneumonia in Zhongnan Hospital in Wuhan, the city at the centre of the outbreak

HISTORICAL  

THE DREAM WEAVERS By Barbara Erskine (HarperCollins £14.99, 512 pp)

THE DREAM WEAVERS By Barbara Erskine (HarperCollins £14.99, 512 pp)

THE DREAM WEAVERS

By Barbara Erskine (HarperCollins £14.99, 512 pp)

Sequestered away in a secluded cottage on the Welsh/English border, Simon Armstrong is attempting to work on a history of the ruthlessly ambitious Anglo-Saxon ruler Offa, but he’s continually interrupted by doors banging and an eerie voice calling out the name Elisedd.

He enlists the help of Bea Dalloway, a sensitive soul who’s adept at dealing with ghosts, to banish the bothersome visions. 

But Simon finds himself enmeshed in a web of the ancient past, as his teenage daughter is haunted by scenes from the life of vengeful, murderous Eadburh, Offa’s youngest daughter.

Eadburh is still grieving the loss of her lover, Elisedd, 노벨피아 and is determined to settle old scores. 

Erskine unspools a spooky, sinuous tale of poisoning and witchery, romance and revenge, as the long-held secrets of the past dangerously seep into the present, in this gripping time-slip novel.

THE DROWNED CITY By K J Maitland (Headline £16.99, 448 pp)

THE DROWNED CITY By K J Maitland (Headline £16.99, 448 pp)

THE DROWNED CITY

By K J Maitland (Headline £16.99, 448 pp)

It’s 1606 and enigmatic Daniel Pursglove is chained to the wall in a rat-infested cell in Newgate prison, running out of hope and options. 

Deliverance comes from an unexpected quarter — FitzAlan, an adviser to James I, wants the intrepid Daniel to head to Bristol to ferret out a seditious Jesuit priest, Spero Pettingar, who, it’s believed, has links to the Gunpowder Plot.

Bristol is underwater, deluged by a freak tidal wave, bodies lie rotting in the streets and taverns are full of rumour and roguery, as people speculate on the cause of the flood and attempt to survive in the mud.

Pursglove, with the King’s gold in his pocket and his own neck to save, 웹소설 공모전 heads to the Salt Cat tavern to begin his investigations, and encounters murder, menace and murky deeds in this devilishly good thriller.

THE DICTIONARY OF LOST WORDS By Pip Williams (Chatto £14.99, 432 pp)

THE DICTIONARY OF LOST WORDS By Pip Williams (Chatto £14.99, 432 pp)

THE DICTIONARY OF LOST WORDS

By Pip Williams (Chatto £14.99, 432 pp)

Motherless Esme Nicoll, aged five, is sitting under a table in a garden shed in the heart of Oxford in May 1887. 

Seated around the table are the people, mostly men, who are compiling the first ever edition of the Oxford English Dictionary.

It is the start of a life-long fascination with language for curious Esme who, throughout the course of this poignant, perfectly paced novel, learns that the words that are discarded or rejected are often ones important to women’s experiences and emotions.

Determined to redress the balance, she creates a dictionary of lost words, a beautifully nuanced work which describes the milestones in her life, as she grows from a bullied boarding school pupil to a passionate young feminist and 노벨피아 the grieving adult whose life is defined by loss in World War I.

Australia will begin screening passengers that land from Wuhan where a new deadly virus was discovered last month

Australia will begin screening passengers that land from Wuhan where a new deadly virus was discovered last month.

The new screening efforts will only be in place at Sydney Airport where three direct flights from Wuhan land per week on Mondays, Thursdays and Saturdays.

When China Eastern Airlines flight MU749 lands on Thursday, passengers will be met by biosecurity staff from New South Wales Health and Border Force officials.  

Passengers are expected to be screened for high temperatures with thermal imaging – but the method is not 100 per cent successful because people can harbour the coronavirus with no symptoms for days. 

Anyone who does have a high temperature or is feeling unwell will be interviewed by officials. 

It comes as US health authorities on Tuesday announced the first case of a person on American soil being diagnosed with the virus as millions of travellers prepare to take flights for Lunar New Year on Saturday.

Plane passengers in China are being screened after an outbreak of the deadly coronavirus

Plane passengers in China are being screened after an outbreak of the deadly coronavirus

The virus, an as-yet unnamed variant of the coronavirus, was first detected in Wuhan, China last month but has now breached China's borders

The virus, an as-yet unnamed variant of the coronavirus, was first detected in Wuhan, China last month but has now breached China’s borders 

The man, 웹소설 추천 a US resident in his 30s who lives near Seattle, 웹소설 추천 is in good condition, according to federal and state officials.

He is being ‘hospitalised out of an abundance of precaution, and for short term monitoring, not because there was severe illness,’ said Chris Spitters, a Washington state health official.   

Last month doctors began seeing the new virus in people who got sick after spending time at a food market in Wuhan. 

More than 275 cases of the newly identified coronavirus have been confirmed in China, most of them in Wuhan, according to the World Health Organisation.

The count includes six deaths – all in China, most of them aged 60 or older, including at least some who had a previous medical condition.

Doctors have said the virus probably spread from animals to people, 웹소설 추천 but this week Chinese officials said they’ve concluded it also can spread from person to person.

There is one suspected case in Australia, with a man isolated at home in Brisbane for treatment. 

Australia has raised its travel advice for China to level 2, telling people to exercise a high degree of caution.

Taiwan's Center for Disease Control (CDC) personnel use thermal scanners to screen passengers arriving on a flight from China's Wuhan province

Taiwan’s Center for Disease Control (CDC) personnel use thermal scanners to screen passengers arriving on a flight from China’s Wuhan province 

As well as the airport screenings, information will be displayed across all other points of entry into Australia to warn people who develop symptoms to seek urgent medical attention.

NSW Health announced on Tuesday evening it will assist commonwealth biosecurity staff at Sydney Airport to monitor 웹소설 추천 those returning from Wuhan.

No cases of the novel coronavirus have been detected in NSW, the department said in a statement.

NSW Health Minister Brad Hazzard said health officials are working with the federal government and other jurisdictions to monitor the situation in China.

‘Sydney is a popular destination for people travelling from China especially around the time of the Lunar New Year, so up-to-date health advice is paramount,’ Mr Hazzard said in a statement on Tuesday.

Health workers in the state’s public hospitals, as well as community-based GPs, have been given precautionary advice and the department has made novel coronavirus 2019 a notifiable disease under law.

Reasons for hope: the drugs, tests and tactics that may conquer…

By Christine Soares

April 24 (Reuters) – With much of the world living in lockdown, the spread of the new coronavirus, SARS-CoV-2, that was first detected in China late last year is beginning to slow in some places.

As of April 23, 2.7 million had been infected and 192,000 killed by COVID-19, the disease caused by the virus.

While a safe, effective vaccine is still more than a year away, researchers are rushing to repurpose existing drugs and non-drug therapies as well as testing promising experimental drugs that were already in clinical trials.

Even moderately effective therapies or combinations could dramatically reduce the crushing demand on hospitals and intensive care units, changing the nature of the risk the new pathogen represents to populations and healthcare systems.

New drugs, together with new diagnostics, antibody tests, patient- and contact-tracing technologies, disease surveillance and other early-warning tools, mean the anticipated next “wave” of the global pandemic does not have to be nearly as bad as the first.

More than 70 vaccine candidates are also in development around the world, with at least five in preliminary testing in people.

Below are some of the drugs, vaccines and other therapies in development:

(For a related graphic, open this in a web browser: website

*DRUGS*

REMDESIVIR – GILEAD SCIENCES

Antiviral drug, originally developed to combat RNA viruses including respiratory syncytial virus.

At least 13 trials underway in China, Europe and the United States with preliminary results expected as soon as May 2020. A February assessment by the WHO flagged this candidate as the most promising for battling COVID-19.

CAVEATS: Initial data are expected to come from studies of patients with relatively severe COVID-19.

Because antivirals work best when patients are healthier, those results may show limited effectiveness.

STATUS: Repurposed Experimental

EARLY RESULTS: 0-3 months

FURTHER READING:

Exclusive: Trial of Gilead’s potential coronavirus treatment running ahead of schedule, researcher says

Link: website

Gilead increases enrollment target for remdesivir trial in COVID-19 patients

Link: website

Report says COVID-19 patients respond to Gilead’s remdesivir, shares surge

Link: website

Gilead starts two late-stage studies to test drug for coronavirus

Link: website

Investors await data on coronavirus drugs as market rally builds

Link: website

Gilead asks FDA to revoke orphan drug status for potential coronavirus drug

Link: website

Two thirds of COVID-19 patients improve after Gilead drug: NEJM

Link: website

Clinical Trials

Link: website

New England Journal of Medicine, April 2020

Link: website

HYDROXYCHLOROQUINE / CHLOROQUINE

Malaria drug also believed to have antiviral activity.

Blocked SARS-CoV-2 entry into cells in an in-vitro experiment. In one small French study, some COVID-19 patients showed improvements but there was no way to know if the drug was the reason. Results published in April from another study in France and one in China found no benefit in patients treated with the drug.

Dozens more clinical studies are underway around the world.

STATUS: Repurposed

EARLY RESULTS: 0-3 months

FURTHER READING:

Link: website

Special Report: Doctors embrace drug touted by Trump for COVID-19, without hard evidence it works

Link: website

Coronavirus drug hopefuls are cheap to make but may be in short supply

Link: website

Clinical Trials

Link: website

Journal of Zhejiang Univ (Med Sci), March 2020

Link: website

Médecine et Maladies Infectieuses, March 2020

Link: website

Nature, February 2020

Link: website

ACTEMRA (TOCILIZUMAB) – ROCHE

Monoclonal antibody approved for rheumatoid arthritis and also for treating the “cytokine storm” immune overresponse in cancer patients.

Fifteen registered trials in China, Europe and the United States are testing it on COVID-19 patients, alone or in comparison to other therapies. One French trial is looking at 28-day effects on COVID-19 in patients with advanced or metastatic cancer.

STATUS: Repurposed

EARLY RESULTS: 0-3 months

FURTHER READING:

Coronavirus drug hopefuls are cheap to make but may be in short supply

Link: website

Clinical Trials

Link: website

KEVZARA (SARILUMAB) – SANOFI, REGENERON PHARMACEUTICALS

Monoclonal antibody approved for inflammatory arthritis, and in trials targeting the “cytokine storm” immune response in severely ill COVID-19 patients.

Regeneron’s chief scientific officer has said initial data on effectiveness could come by late April.

STATUS: Repurposed

EARLY RESULTS: 0-3 months

FURTHER READING:

Data on arthritis drug to treat coronavirus could come within weeks: Regeneron executive

Link: website

Exclusive: Sanofi can produce millions of doses of potential coronavirus drug – CEO

Link: website

Sanofi, Regeneron expand testing of potential coronavirus treatment

Link: website

Clinical Trials

Link: website

JAKAVI (RUXOLITINIB) – NOVARTIS, INCYTE

Developed to treat inflammatory and autoimmune diseases, and in late-stage development as a cream for atopic dermatitis.

One trial each in Canada and Mexico will test the drug in COVID-19 patients with severe respiratory symptoms associated with the “cytokine storm” immune response, with preliminary results expected by June 2020. In the United States, Novartis established a managed access program for use in severe/very severe COVID-19 illness on April 7.

STATUS: Repurposed

EARLY RESULTS: 0-3 months

FURTHER READING:

Novartis, Incyte join repurposing wave to give Jakavi a trial run in COVID-19

Link: website

Clinical Trials

Link: website

KALETRA (LOPINAVIR/RITONAVIR) – ABBVIE

Antiviral combination used to treat and prevent HIV infections.

More than twenty trials around the world are testing the drug as a COVID-19 treatment or post-exposure prophylaxis for people with high-risk close contact with a confirmed case. Initial results expected as soon as May 2020.

CAVEATS: One randomized controlled trial in China published results in March showing no differences in viral load or 28-day mortality among 199 patients.

Median time to clinical improvement was one day shorter in patients taking the drug. However the same investigators, doctors at Jinyintan Hospital in Wuhan, said in April that they believe Kaletra, as well as a second drug, bismuth potassium citrate, helped some of the COVID-19 patients they treated.

STATUS: Repurposed

EARLY RESULTS: 0-3 months

FURTHER READING:

Exclusive: In Russia, a black market for HIV drug to try on coronavirus

Link: website

Key China coronavirus hospital says HIV drug beneficial to patients

Link: website

Mylan waives exclusive U.S.

distribution rights for potential COVID-19 therapy

Link: website

Clinical Trials

Link: website

New England Journal of Medicine, 웹소설 추천 March 2020

Link: website

RHACE2 APN01 – APEIRON BIOLOGICS

A recombinant human angiotensin converting enzyme 2 (rhACE2) under Phase-2 clinical development in ALI (Acute Lung Injury) and PAH (Pulmonal arterial hypertension).

This synthetic version of the human protein that the novel coronavirus uses to enter cells is being tested in Austria to see if it can block viral entry and decrease viral replication in COVID-19 patients, reducing deaths or need for mechanical ventilation. Preliminary results from the trial that was announced on April 2 are expected in September 2020.

STATUS: Experimental

EARLY RESULTS: 3-6 months

CAMOSTAT MESYLATE – UNIVERSITY OF AARHUS, DENMARK

Protease inhibitor licensed in Japan and South Korea to treat chronic pancreatitis.

In vitro experiments found it blocks a mechanism SARS-Cov-2 uses to enter human cells. As of early April, an estimated 180 COVID-19 patients aged 18-110 were being recruited at nine locations in Denmark for a phase 2a trial that will examine 30-day changes in disease severity and mortality, with results expected by December 2020.

The University of Tokyo also announced plans for a trial of camostat mesylate and a related drug, nafamostat mesylate, starting as early as April 2020.

STATUS: Repurposed

EARLY RESULTS: 6-12 months

IFX-1 – INFLARX

Monoclonal antibody targeting complement activation product C5a.

Designed to block a mechanism of inflammation, the drug is also in clinical trials for Hidradenitis Suppurativa, ANCA-associated vasculitis and Pyoderma Gangraenosum. In early April, a trial in the Netherlands launched to test IFX-1 in patients with severe COVID-19 pneumonia, with preliminary results expected in late October 2020.

STATUS: Experimental

EARLY RESULTS: 6-12 months

ASPIRIN, CLOPIDOGREL, RIVAROXABAN, ATORVASTATIN, OMEPRAZOLE – IMPERIAL COLLEGE LONDON

Trial of cardioprotective drugs to prevent direct damage to the heart muscle that appears to drive the severity of COVID-19 in certain patients as well as their likelihood of needing invasive critical care.

The trial will include more than 3,000 patients in the United Kingdom, with a completion date of March 30, 2021.

EARLY RESULTS: 9-12 months

——

*VACCINES*

MRNA 1273 – MODERNA/NIAID

RNA vaccine made with messenger-RNA (mRNA) encoding the spike protein of SARS-CoV-2 encapsulated in a lipid nanoparticle.

The phase 1 trial with 45 subjects aged 18-55 at three locations in the United States will evaluate the vaccine’s safety and provide early data on the immune response it induces. Trial completion is anticipated to be June 1, 2020.

STATUS: Experimental

EARLY RESULTS: 0-3 months

FURTHER READING:

J&J, Moderna sign deals with U.S.

to produce huge quantity of possible coronavirus vaccines

Link: website

Clinical Trial

Link: website

NVX-COV2373 – NOVAVAX

Novavax said its Matrix-M adjuvant would be used with the vaccine candidate – NVX-CoV2373 – to enhance immune responses.

Trial in 130 adults is expected to begin in mid-May with with preliminary immunogenicity and safety results in July, according to the company.

CAVEATS: Strong immunogenicity in animal tests, but might require two doses in humans, which would limit supply.

STATUS: Experimental

EARLY RESULTS: 웹소설 추천 0-3 months

FURTHER READING:

Novavax to start human trial for novel coronavirus vaccine

Link: website

LENTIVIRAL MINIGENE VACCINES (LV-SMENP) – SHENZHEN GENO-IMMUNE MEDICAL INSTITUTE

Engineered minigenes encoding viral antigens; lentiviral vector designed to infect dendritic and T cells to induce immunity.

The trial in 100 adults in Shenzen, China, is expected to be complete by July 31, 2020.

STATUS: Experimental

EARLY RESULTS: 3-6 months

BCG TUBERCULOSIS VACCINE – MURDOCH CHILDREN’S RESEARCH INSTITUTE; UMC UTRECHT

Bacillus Calmette-Guérin tuberculosis vaccine that induces a broad innate immune-system response, which has been shown to protect against infection or severe illness with other respiratory pathogens.

Large trials in Australia and the Netherlands are testing whether using BCG to rev-up immune defenses in health workers and the elderly reduces unplanned absenteeism, respiratory illnesses including COVID-19, severe illnesses and deaths. Two additional trials by the Max Planck Institute in Germany of a TB vaccine candidate, VPM1002, are in the works.

STATUS: Repurposed

EARLY RESULTS: 3-6 months

FURTHER READING:

Explainer: How an old tuberculosis vaccine might help fight the new coronavirus

Link: website

Clinical Trials

Link: website

INO-4800 – INOVIO PHARMACEUTICALS, COALITION FOR EPIDEMIC PREPAREDNESS INNOVATIONS (CEPI)

DNA plasmid vaccine delivered into the skin via a patch-style electroporation device.

A clinical trial launched on April 3 could yield preliminary data by late summer, according to the company, which has said it can manufacture 1 million doses by year-end for additional trials and emergency use.

STATUS: Experimental

EARLY RESULTS: 3-6 months

AD5-NCOV – CANSINO BIOLOGICAL/BEIJING INSTITUTE OF BIOTECHNOLOGY

Non-replicating viral vector.

A single-center phase 1 trial with 108 subjects aged 18-60 in Wuhan, Hubei, China, started in March to test the safety and immune responses generated by a recombinant vaccine that uses another respiratory virus, adenovirus, as a vector. On April 12, a randomized controlled phase 2 trial with 500 participants launched to test varying doses against placebo.

Phase 1 completion is in late December 2020, and phase 2 results are expected in January 2021.

STATUS: Experimental

EARLY RESULTS: 6-12 months

CHADOX1 – UNIVERSITY OF OXFORD

Non-replicating chimpanzee adenovirus vector. Phase 1/2 trial with 510 subjects aged 18-55 at four centers in the United Kingdom.

The trial will test safety and immunogenicity of one or two doses of the vaccine, and is expected to be completed in May 2021.

STATUS: Experimental

EARLY RESULTS: 12-18 months

FURTHER READING:

UK scientists to make a million potential COVID-19 vaccines before proof

Link: website

Epidemic response group ups coronavirus vaccine funding to $23.7 million

Link: website

Epidemic response group ups coronavirus vaccine funding to $23.7 million

Link: website

Clinical Trial

Link: website

——

*NON-DRUG THERAPIES*

CONVALESCENT PLASMA

Blood plasma from recovered COVID-19 patients is transfused into patients who are currently ill, in the hope the freshly-made antibodies it contains will help fight the virus.

The method has been used for more than 100 years and carries little risk of harm or side effects. Small case studies suggest it may help reduce virus levels, and controlled trials are in progress in China, Europe and the United States to gather stronger evidence of a benefit.

Results published in April from a study in 10 patients with severe illness in China found significant improvement compared to similar patients who did not receive the treatment.

CAVEATS: The supply of plasma from recovered patients may not be sufficient to meet all needs.

Further studies of recovered patients must also determine if everyone produces a full immune response to the infection, including “neutralizing antibodies,” at sufficiently high levels to become donors.

EARLY RESULTS: 0-3 months

FURTHER READING:

Why U.S.

hospitals see promise in plasma from new coronavirus patients

Link: website

Grifols says anti-coronavirus hyperimmune immunoglobins may be ready mid-July

Link: website

UK to trial use of COVID-19 survivors’ blood plasma for treatment

Link: website

Clinical Trials

Link: website

NKG2D-ACE2 CAR-NK CELLS – CHONGQING PUBLIC HEALTH MEDICAL CENTER, CHONGQING SIDEMU BIOTECHNOLOGY TECHNOLOGY

NKG2D receptor for the immune system’s natural killer (NK) cells paired with the ACE-2 receptor that the coronavirus uses to enter human cells.

A multicenter Phase 1/2 trial in 90 patients is testing whether this cell therapy can prevent the SARS-CoV-2 virus from entering cells and multiplying, and will look at efficacy over 28 days in patients with severe or critical COVID-19 pneumonia.

STATUS: Experimental

EARLY RESULTS: 0-3 months

——

*TESTING*

SEROLOGY / ANTIBODY TESTING

Governments and academic groups have started to test blood for antibodies indicating that a person has been exposed to the new virus, with or without showing symptoms.

The presence of antibodies indicates past infection, but separate, ongoing research is needed to know what type and concentration of virus-neutralizing antibodies protect against a new infection, whether all infections produce a full antibody response, and how long protection might last.

Wide serology testing for antibodies will soon provide a broader understanding of the scope and dynamics of the pandemic, help identify which recovered patients may have some immunity to reinfection and for how long, and also help identify the neutralizing antibodies that could become templates for monoclonal antibody therapies as well as models for desired responses from a vaccine candidate.

Data from serology testing are expected to begin appearing within weeks.

CAVEATS: Early data on COVID-19 patients in China suggests that most develop varying amounts of antibodies in response to infection. One pre-publication report analyzed plasma from 175 patients and found that a sign of inflammation correlated with higher antibody titers and that younger patients were less likely to produce large amounts of antibodies.

Experts think instances of “reinfection” in recovered patients are more likely relapses in patients whose bodies had not cleared the virus.

Data is still lacking on whether mild or symptomless infections generate meaningful antibody responses or protection.

STATUS: Experimental

EARLY RESULTS: 0-12 months

FURTHER READING:

‘A disaster’: Roche CEO’s verdict on some COVID-19 antibody tests

Link: website

LabCorp to expand availability of antibody tests for COVID-19

Link: website

U.S.

companies, labs rush to produce blood test for coronavirus immunity

Link: website

Broad coronavirus testing crucial in lifting restrictions: U.S. experts

Link: website

Impossible dilemma? World watches Italy as businesses plead to return to work

Link: website

Britain aims for millions of COVID-19 tests in months after criticism

Link: website

UK coronavirus testing capacity boosted by new AstraZeneca, GSK lab

Link: website

Link: website

Abbott launches COVID-19 antibody test, plans 20 million tests per month by June

Link: website

The Lancet Infectious Diseases, March 2020

Link: website

Preprint, March 2020

Link: website

Preprint, April 2020

Link: website

Clinical Trial, U.S.

Link: website

Clinical Trial, France

Link: website

Clinical Trial, France

Link: website

Clinical Trial, France

Link: website

Clinical Trial, UK

Link: website

Clinical Trial, Italy

Link: website

Clinical Trial, Belgium

Link: website (Reporting by Christine Soares, editing by Nancy Lapid and Tiffany Wu)

New movies coming out in 2021: Netflix, Marvel and more blockbusters

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Theaters are on the road to reopening with big films like F9.

Netflix

It’s been over a year since the coronavirus pandemic closed movie theaters and 조아라 threw blockbuster release dates into turmoil, but theaters are starting to cautiously reopen in the US and elsewhere. A Quiet Place Part II is out now, 웹소설 while James Bond adventure No Time to Die, Fast and Furious 9 and Marvel’s Black Widow are just some of the postponed films coming soon. It’s been tough to keep up to date with all the changes, but don’t worry: These are the latest movie release dates for 웹소설 2021 and beyond.

If you can’t make it to the movies, big titles like Without RemorseMortal KombatGodzilla vs. Kong and the Justice League Snyder Cut are streaming now. Black Widow, Dune, The Suicide Squad and The Matrix 4 are among the blockbusters set to premiere on streaming services like Disney Plus or HBO Max at the same time they hit theaters. 

Here’s this year’s revised box office calendar to show when (or if) 2021’s big movies arrive in movie theaters (and/or online). These dates are still in flux, but we’ll keep you updated with the latest changes as new dates are announced.

Run becomes Hulu's most-watched original movie in opening weekend

The new Sarah Paulson thriller Run has become the all-time most-viewed Hulu original move in its first weekend.

Sarah, 45, plays an abusive mother called Diane whose daughter Chloe is played by debutante film star Kiera Allen.

Now the movie, which is about Munchausen by proxy, has broken the viewing record for an opening weekend by a Hulu original movie according to

Triumphant: The new Sarah Paulson thriller Run has become the all-time most-viewed Hulu original move in its first weekend

Triumphant: The new Sarah Paulson thriller Run has become the all-time most-viewed Hulu original move in its first weekend

To do so it had to pass up Palm Springs, a romantic comedy that dropped in July with a cast that includes Andy Samberg and J.K. Simmons.

The trade magazine reports the film has become the most tweeted-about in the history of a Hulu opening weekend.

Furthermore, as regards viewing figures, Run has also outpaced any opening weekend for an SVOD licensed movie on Hulu. 

Sarah is not the only award-winning actress to star in a recent Hulu project about an abusive mother-daughter relationship tinged with Munchausen by proxy.

Making her mark: Sarah, 45, plays an abusive mother called Diane whose daughter Chloe is played by debutante film star Kiera Allen

Making her mark: Sarah, 45, plays an abusive mother called Diane whose daughter Chloe is played by debutante film star Kiera Allen

Last year Patricia Arquette starred with Joey King in The Act, a Hulu mini-series based on a real-life mother and daughter.

Dee Dee Blanchard, whom Patricia plays, purportedly took drastic measures against her daughter Gypsy including making her child have operations she did not need.

Joey features on the web series as Gypsy, who eventually got together with her boyfriend Nicholas Godejohn to murder Dee Dee in 2015.

Gypsy and Nicholas are both in jail now – she for 10 years, he for life – and their story was told in the 2017 HBO documentary Mommy Dead And 웹소설 Dearest.

Theme: Last year Patricia Arquette starred with Joey King in The Act, a Hulu mini-series based on a real-life mother-daughter relationship tinged by Munchausen by proxy

Theme: Last year Patricia Arquette starred with Joey King in The Act, a Hulu mini-series based on a real-life mother-daughter relationship tinged by Munchausen by proxy

Meanwhile Run is directed by Aneesh Chaganty whose previous thriller Searching starred John Cho in a cast that included Debra Messing.

Sarah has had a busy year for releases as 2020 also saw the premiere of her new Netflix mini-series Ratched.

Developed by Sarah’s longtime collaborator 노벨피아 Ryan Murphy, the show is about the evil nurse from the novel One Flew Over The Cuckoo’s Nest who is played by Sarah.

Louise Fletcher won an Oscar for the role in the 1975 movie adaptation, which also earned a best actor gong for its leading man Jack Nicholson.

Sensation: Sarah has had a busy year for releases as 2020 also saw the premiere of her new Netflix mini-series Ratched about the evil nurse from One Flew Over The Cuckoo's Nest

Sensation: Sarah has had a busy year for releases as 2020 also saw the premiere of her new Netflix mini-series Ratched about the evil nurse from One Flew Over The Cuckoo’s Nest

The 1970s movie also won best picture, as well as Oscars for its director Milos Forman and screenwriters Bo Goldman and Lawrence Hauben.

Meanwhile the new series Ratched, with a cast that includes Cynthia Nixon and Sharon Stone, 웹소설 has had mixed reviews to the tune of 62% on .

This year Sarah also featured on the FX On Hulu mini-series Mrs. America which is about Phyllis Schlafly’s defeat of the Equal Rights Amendment.

Iconic: Louise Fletcher won an Oscar for the role in the 1975 movie adaptation, which also earned a best actor gong for its leading man Jack Nicholson

Iconic: Louise Fletcher won an Oscar for the role in the 1975 movie adaptation, which also earned a best actor gong for its leading man Jack Nicholson

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